Which condition is characterized by target-like lesions with central blister and often self-limiting?

• A. Erythema multiforme
• B. Basal cell carcinoma
• C. Pemphigus vulgaris
• D. Stevens-Johnson syndrome

Answer: (A)

Target-like, or targetoid, lesions with a central blister are classic for erythema multiforme. These lesions usually show three zones: a dark or vesicular center, a surrounding pale area, and an outer red ring. They often appear on the hands and feet and can involve mucous membranes in the more extensive form. The illness is typically self-limiting, often resolving within a couple of weeks, and management centers on supportive care and removing triggers such as a recently started drug or treating a concurrent herpes simplex infection if involved. The other conditions don’t fit this pattern: basal cell carcinoma presents as a slow-growing pearly papule with telangiectasias; pemphigus vulgaris features fragile, rupturing bullae with mucosal involvement and a positive Nikolsky sign; Stevens-Johnson syndrome is a severe, mucosa-involving reaction with systemic illness and widespread skin detachment.