Procaine is metabolized to PABA in peripheral tissues and plasma. Which is a true statement about this metabolism?

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Multiple Choice

Procaine is metabolized to PABA in peripheral tissues and plasma. Which is a true statement about this metabolism?

Explanation:
Procaine is an ester local anesthetic, and in plasma and peripheral tissues esterases rapidly hydrolyze the ester bond to yield para-aminobenzoic acid (PABA) and diethylaminoethanol. Therefore, the metabolite formed is PABA. Lactic acid, urea, and glucose are not products of this hydrolysis pathway. The production of PABA also helps explain why procaine can be associated with allergic reactions in some individuals, since PABA is a known allergen.

Procaine is an ester local anesthetic, and in plasma and peripheral tissues esterases rapidly hydrolyze the ester bond to yield para-aminobenzoic acid (PABA) and diethylaminoethanol. Therefore, the metabolite formed is PABA. Lactic acid, urea, and glucose are not products of this hydrolysis pathway. The production of PABA also helps explain why procaine can be associated with allergic reactions in some individuals, since PABA is a known allergen.

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