Is isotretinoin teratogenic?

• A. Yes
• B. No
• C. Only in high doses
• D. Not known

Answer: (A)

Isotretinoin is a highly teratogenic medication; exposure during pregnancy can cause major birth defects or fetal loss. It disrupts retinoic acid signaling crucial for normal development, leading to defects in the face, heart, brain, spine, and other organs. Because of this strong risk, isotretinoin is strictly contraindicated in pregnancy, and patients of reproductive potential must use reliable contraception and undergo regular pregnancy testing before, during, and after treatment. That’s why the correct answer is Yes. The other options are not accurate: the risk is not limited to high doses, it is well established, and it is not unknown.