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Multiple Choice

Granuloma annulare histology shows which feature?

Granuloma annulare is defined by a dermal granulomatous reaction where zones of degenerated collagen (necrobiosis) are surrounded by palisading histiocytes. The central area shows collagen with breakdown and mucin deposition, making this collagen degeneration the characteristic histologic finding. The granulomas are typically non-necrotizing, which distinguishes them from necrotizing granulomas seen in other conditions. Eosinophilic infiltrates are not a hallmark of this process, and acanthosis refers to epidermal thickening—not the primary dermal granulomatous change seen in granuloma annulare.

Granuloma annulare is defined by a dermal granulomatous reaction where zones of degenerated collagen (necrobiosis) are surrounded by palisading histiocytes. The central area shows collagen with breakdown and mucin deposition, making this collagen degeneration the characteristic histologic finding. The granulomas are typically non-necrotizing, which distinguishes them from necrotizing granulomas seen in other conditions. Eosinophilic infiltrates are not a hallmark of this process, and acanthosis refers to epidermal thickening—not the primary dermal granulomatous change seen in granuloma annulare.